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and the tyrosine kinase receptors of growth factors 13,14 , as well as components of the c-Jun N-terminal kinase (JNK) and p38 kinase (p38MAPK) pathways that induce apoptosis 15

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A cross-sectional study of 700 community-living, physically disabled women over the age of 65 found that vitamin B 12 -deficient women were twice as likely to be severely depressed as non-deficient women (97)

It alleviates the symptoms of abdominal pain, diarrhea and constipation in patients with IBS by regulating the composition of the intestinal microbiota