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doi: 10.1152/physrev.00026.2013 Summary Keywords antioxidant, calcium, calcium oxalate, mitochondria, nephrolithiasis, oxidative stress, reactive oxygen species, urolithiasis Citation Chaiyarit S and Thongboonkerd V (2020) Mitochondrial Dysfunction and Kidney Stone Disease

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The key differences that make this fragment scientifically interesting are: Absence of IGF-1 stimulation: Unlike full-length GH, this compound does not appear to stimulate hepatic IGF-1 production in laboratory models, an important distinction for researchers wishing to study metabolic GH-related pathways without the confounding variable of IGF-1 pathway activation