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If you have been sourcing from gray-market or "research use only" vendors: The risks are real and not hypothetical contamination, inaccurate dosing, and the absence of any clinical oversight

An unlicensed medicinal product should not be supplied where an equivalent licensed medicinal product can meet the special needs of the patient

J Nutr 2005;135:110612

The ability to counteract side effects while leaving desired effects intact is a holy grail of modern medical research as it would improve therapeutic benefits for a number of drugs