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In a review that synthesized a few decades of data, Anisimov shared the results of his investigation of the roles of small peptides isolated from different organs and tissues, such as the thymus gland and the pineal gland, on the mechanisms of aging

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MRI examinations have uncovered microbleeds in the deep layers of the motor cortex in ALS patients, while the precise mechanisms driving this BBB impairment in ALS remain elusive [243]

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Moreover, the stage at which neurogenesis is affected differs from study to study, with some models displaying defects only at the maturation stage of neurogenesis (Hollands et al., 2017)