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Coumarins are natural inhibitors of VKORC1 found in many medicinal herbs

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Selenium and alpha-lipoic acid (ALA) also support glutathione recycling

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The CBS OPT and L2HGDH OPT were then constructed in pCDH-CMV-Nluc-P2A-copGFP-T2A-Puro (#73037, Addgene), with the Nluc-P2A-coGFP genes removed