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This causes physical (body) and psychological (brain) dependence an adaptation that makes it difficult to function without opioids

The slow, insidious nature of PD makes prevention and even early detection especially difficult

[DOI] [PMC free article] [PubMed] [Google Scholar] 312.Sanmartn C., Plano D., Sharma A.K., Palop J.A

*Correspondence: Ying Huang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Qin X., Sheth S.U., Sharpe S.M., Dong W., Lu Q., Xu D., Deitch E.A