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A large 2009 placebo-controlled double-blind randomized trial of 2-mg and 4-mg NRT gum (Nicorette original flavor) [43] looked at quitting smoking via gradual reduction: replacing cigarettes over time with NRT gum

FIGURE 4 5 MCI, neurodegeneration, and other neurological disorders As described earlier, there is growing evidence that non-smokers exposed to SHS are at an increased risk of developing MCI (Chen, 2012

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