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KPV is a short tripeptide fragment derived from the C-terminus of alpha-MSH (alpha-melanocyte-stimulating hormone), studied primarily for anti-inflammatory pathways
5.2 Microbial factors directly modulating -cells: LPS, indoles and BefA SCFAs, particularly butyrate, protect -cells not only by enhancing GLP-1 secretion but also through profound immunomodulatory effects that attenuate islet inflammation
One of them is sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables
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It can cause gastroenteritis, often with fever, that is typically mild and self-limited, lasting 1 to 2 days
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