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The weight-lowering effect is likely mediated by enhanced energy expenditure 23 , modulation of the gut microbiota leading to increased fecal energy excretion 24 , and fermentation of dietary fiber into SCFAs, which promote lipid oxidation and suppress systemic lipogenesis 25

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doi: 10.1007/s12649-023-02189-2 66 SomatHAThaniNMMustaphaWALimSJSengNSRahmanHAet al

The VEGFR2-independent mechanism involves Src kinase-mediated phosphorylation of caveolin-1, disrupting the inhibitory interaction between caveolin-1 and eNOS

The guidelines here are a bit more flexible, but our professional recommendation is to stick with consistency