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Anakinra is an IL-1 receptor antagonist used for treating moderate-to-severe RA that has been unresponsive to initial disease-modifying anti-rheumatic drug (DMARD) therapy

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4.3 Reproduction To ensure a required gene expression pattern to support embryonic development, the maternal (oocyte) and paternal (sperm) epigenome are remodeled to reach totipotency, driving cellular differentiation toward all cell types (Ross and Sampaio, 2018), including embryonic and extraembryonic ( i.e ., placenta) cell types