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19, 20, 21 The TJ also serves as an intracellular hub where myriad of proteins reside alone or in a complex

The neuroprotection of verbascoside in Alzheimers disease mediated through mitigation of neuroinflammation via blocking NF-B-P65 signaling

10.3389/ftox.2022.867748 31 PickeringG.EsteveV.LoriotM

This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated

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