This GRAS designation does not imply FDA approval for therapeutic, drug, or compounded use , and it is sometimes misrepresented in marketing copy
22 To estimate the strength of the association, univariable (binary) logistic regression models were used to calculate the odds ratio (OR)
In this situation, it can be challenging to demonstrate B12 deficiency even when there are typical symptoms (including neuropathy-like paraesthesia and numbness), as serum B12 concentrations may be just within, or sometimes above, the normal range due to the oral supplementation
In experiments on various animal species (mostly rats), its healing properties have been shown to extend to various other tissue types, including muscles, tendons, and ligaments
B12 levels can decrease with age, as well as being lower in people who have undergone weight loss surgery, or suffer from multiple sclerosis, pernicious anaemia, Crohns or celiac disease