[DOI] [PubMed] [Google Scholar] 51.Huang ZZ, Yang HP, Chen CJ, Zeng ZH, Lu SC
Interestingly, in one study, stress signaling transcripts strongly reacted to a single excess light trigger at 1000 mol m 2 s 1 photon flux density in non-primed Arabidopsis plants, while the same transcripts in primed plants (repeatedly pre-treated with excess light at 1000 mol m 2 s 1 ) remained largely unaffected
Such findings suggest a sophisticated level of control over ChaC1s role in cellular responses to stress, particularly in managing intracellular GSH levels ( 3.1.1.2 ATF4 and ATF3 CHAC1, an enzyme that degrades intracellular glutathione, is a direct target of the transcription factor ATF4, activated by UPR signals via the PERK-EIF2A pathway
2 Further research has also demonstrated that GST is expressed abundantly in tumor cells and associated closely to carcinogenesis, tumor formation, and chemotherapy resistance
doi: 10.1016/j.redox.2015.07.012