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Reduced GSH levels shown by decreases in this ratioboth in the plasma and intracellularlyreflect intracellular shifts in oxidative burden and are indicative of immune dysfunction and progression of various disease states such as infection, sepsis, and age-related immune system decline (Morris et al., 2012

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Saber S., Mahmoud A.A.A., Helal N.S., El-Ahwany E., Abdelghany R.H

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However, their clinical application requires rigorous evaluation of therapeutic efficacy, comprehensive safety profiling, and well-defined patient selection criteria

Pharmacological inhibition of ATG4B-dependent autophagic degradation of TBK1 was shown to increase the overall antiviral response (192)