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One notable difference is that tirzepatide is a dual-agonist (GLP-1 and GIP) while retatrutide is a triple-agonist (GLP-1, GIP, and glucagon)

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Immunostaining of the fat pad for UCP1 revealed robust browning of white adipose tissue, which on day 3 was faster and more pronounced than previously reported after 4 weeks of CR 34 (Fig

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