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While glutathione is naturally present in the body and available through certain foods, factors like stress, illness, and age can deplete its levels

These findings align with the observed glycogen accumulation in the mutant CMs, suggesting a shift towards enhanced glycogen storage as a result of the PRKAG2 mutation

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Abbreviations AD: Alzheimers disease APOE: Apolipoprotein E ASC: Apoptosis-associated speck-like protein containing a CARD BDNF: Brain-derived neurotrophic factor CASP1: Caspase 1 CLEC7A: C-type lectin domain containing 7A CTCF: Corrected total cell fluorescence DAM: Disease-associated microglia DAMP: Damage-associated molecular pattern EV: Extracellular vesicle GSDMD: Gasdermin D GSH: Glutathione GSHee: Glutathione ethyl ester LDH: Lactate dehydrogenase LPS: Lipopolysaccharide MGnD: Microglial neurodegenerative MSU: Monosodium urate crystals MDP: Muramyl dipeptide NGF: Nerve growth factor NT3/4: Neurotrophin 3/4 NLRP1/3: NLR family pyrin domain containing 1/3 PAMP: Pathogen-associated molecular pattern References Abbott A

Despite progress in dermatology, conventional treatments for Atopic Dermatitis remain limited in their ability to provide long-term remission or prevent recurrence