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These cardiovascular benefits may reduce the risk of heart disease, stroke, and other cardiovascular complications associated with obesity and metabolic dysfunction

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Lancet 377:19291937 Creager MA, Olin JW, Belch JJ, Moneta GL, Henry TD, Rajagopalan S, Annex BH, Hiatt WR (2011) Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication

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