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They inhibit Nrf2 translocation into the nucleus and enhance NFB activation promoting inflammation and oxidative damage (Laforge et al., 2020)

Statements Author contributions ZQ: Writing original draft, Conceptualization

Ferroptosis: iron release mechanisms in the bioenergetic process

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Breakthrough studies reveal that fucoxanthin (FX) establishes an AMPK/Nrf2/TLR4 tripartite regulatory network, achieving molecular-level metabolic modulation through enhanced AMPK-Thr172 phosphorylation, reduced SREBP-1c nuclear translocation, and downregulated FAS and ACC expression