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Further studies are needed to confirm the lower B12 levels in relation to obesity or semaglutide use, and their effect when combined with GLP-1 drugs

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Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities

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Available at: fda.gov