Rajoka et al., 2019)
Pritchard JR, Lauffenburger DA, Hemann MT
Catabolic states Pathogenesis Catabolic states CYP2E1 activity, shunting hepatic metabolism to gluconeogenesis Glucose precursors for glucuronidation Production of NAPQI) * Causes: Malnutrition, post-surgical patients, AIDS
Loi M, Renaud JB, Rosini E, Pollegioni L, Vignali E, Haidukowski M, Sumarah MW, Logrieco AF, Mule G (2020) Enzymatic transformation of aflatoxin B(1) by Rh_DypB peroxidase and characterization of the reaction products
ALL cells themselves can alter the endosteal and vascular compartments of the niche12 and induce apoptosis of osteoblast cells.17 The remodelled niche is dynamically transient and on exposure to chemotherapeutic agents, ALL cells can release CCL3 and cytokines TGF-1 and GDF15, conferring chemoresistance by activating the TGF- signaling pathway.12 It may be possible to overcome this resistance by disrupting the interactions between leukemia cells and the BM environment