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While oral medications can help with symptoms, they often take a long time to absorb and can cause an upset stomach
When administered orally at a dosage of 1 mg/kg/day for 21 days, it effectively reduced synovial inflammation, pannus formation, cartilage destruction, and bone erosion in a rat model of RA
Cell Microbiol (2005) 7(12):170713
Alternative Routes of Administration & the First-Pass Effect There are several reasons for different routes of administration used in clinical medicine ( Table 33 )for convenience (eg, oral), to maximize concentration at the site of action and minimize it elsewhere (eg, topical), to prolong the duration of drug absorption (eg, transdermal), or to avoid the first-pass effect (sublingual or rectal)