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Early phase trials conducted in Croatia for inflammatory bowel disease reported safety with no toxicity, but detailed data never appeared in peer-reviewed literature

While LF is generally well-tolerated, some side effects such as temporary fecal loosening have been noted, particularly with oral administration, necessitating careful monitoring during extended use ( 4.3 Probiotics 4.3.1 Definitions, biological functions, and areas of application Probiotics are live microorganisms that offer health benefits

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140 In recent years, research on gut microbes has become more extensive, and people have gradually realized the close relationship between gut microbes and human health