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This may produce higher average but lower real-world applicability

This rapid increase has been argued to be due either to a release of IGF-1 stores in tissues or due to a proteolytic cleavage of IGFBP-3 either in the plasma or in tissue

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In some embodiments, the otic composition or formulation comprises less than 3% by weight of C1-C4 alcohols or C1-C4 glycols

Due to the high discontinuation rates observed in early trial phases, especially for the twice-daily formulation, the development team decided not to advance this dosing regimen into Phase III research