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B12 shots and sublingual B12 are superior to oral tablets for absorption, especially if you have GI issues

Short-course studies report no overt toxicity at commonly used doses, but programs should include organ-system panels, cardiovascular telemetry where relevant, and pathology review for chronic exposures

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LineweaverBurk plot assay using L-tyrosine as substrate indicated 12b as a competitive inhibitor

Death due to poisoning is caused by excessive cholinergic effects such as bronchospasms, hypersecretion from cholinergic innervated glands (especially critical in lungs and bronchi), and cardiac disturbances caused by vagotonus and anoxia