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The peptide also appears to have some direct effects on peripheral tissues beyond the central nervous system, including potential metabolic effects, cardiovascular influences, and immunomodulatory properties

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Both aerobic exercise and resistance training have been shown to increase glutathione levels and enhance the activity of related enzymes

C32 is the second active-site cysteinyl residue of PfGrx and C88 is the third cysteinyl residue, which is in the proximity of the active site and can also undergo redox modifications 14,26,30

Chem Rev 117:1276412850