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Placebo (FOURIER trial, N=27,564) Monitoring recommended / fasting lipid panel every 4 to 12 weeks after initiation Prescriber disclosure / always required for any new supplement How Repatha (Evolocumab) Works and Why Metabolism Matters Evolocumab is a fully human IgG2 monoclonal antibody that binds proprotein convertase subtilisin/kexin type 9 (PCSK9), blocking PCSK9 from degrading LDL receptors on hepatocytes

No evidence for caspase-dependent apoptosis in acetaminophen hepatotoxicity

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Giralt S, Khouri I, Braunschweig I, Ippolitti C, Claxton DF, Donato M, Cohen A, Davis M, Andersson B, Anderlini P, Gajewski J, Kornblau SM , Andreeff M, Przepiorka D, Ueno NT, Molldrem J, Champlin RE

2012;37(2):E10918