Nevertheless, many research peptides for skin care and anti-aging lack extensive human trials and there are reasons for caution, especially for those considering investigating therapeutic uses of these peptides on a long-term basis
MitoTEMPOs targeted action protects mitochondrial function and reduces lipid ROS formation, safeguarding both alveolar epithelial and endothelial cells from ferroptotic cell death (97)
Freites-Martinez A, Santana N, Arias-Santiago S, Viera A
doi: 10.5507/bp.2016.044 113 PanH.YangS.KulyarM
Key Points The growth hormone (GH)insulin-like growth factor (IGF) axis consists of central neuro-anatomical, regulatory and genetic systems, and the peripheral intracellular GH signalling pathway The introduction of recombinant human GH (rhGH) in 1985 ended the phase of pituitary-derived human growth hormone (hGH) and its associated limitations and risks, opening the possibility of widespread clinical use GH deficiency (GHD) is a syndrome with many different causes and is associated with alterations in growth, body composition and metabolism In some non-GHD short stature disorders, rhGH has been proved effective and is used as a surrogate for the currently unknown, pathophysiologically appropriate treatment Risks of hGH therapy might relate to its direct effects on growth, its anti-insulin action and its cell-proliferating activity
