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These changes are subtle in the first weeks and more noticeable by the end of the first cycle

Nrf2 Nuclear Factor-Erythroid-2-Related Factor 2 ARE Antioxidant Response Element the antioxidant response element is a cis-acting enhancer sequence containing enhancer regions E1 and E2 that mediate transcriptional activation of genes in cells exposed to oxidative stress including a broad spectrum of circumstances (such as an increased production of free radical species within the cell or by pro-oxidant xenobiotics) that are thiol reactive and mimic an oxidative insult

Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

PMID: 9733495

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