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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 80% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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Antioxidant, pentose phosphate pathway and nitrogen assimilation enzymes The levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), ascorbate peroxidase (APX), glutathione reductase (GR), glutathione S-transferase (GST), glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6GPD), and nitrate reductase (NRA) were measured using the extraction method described by Angelini and Federico 50 and Balotf et al

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