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In conclusion, our data suggest that GSSG is a potent and clinically relevant sensitizer for TNF-induced hepatotoxicity in NAFLD, which represents a potential therapeutic target for NAFLD

These organelles are devoid of catalases and the AsA-GSH cycle acts as the major H 2 O 2 metabolizing pathway in these photosynthetic organelles

Inhibition of a methionine adenosyltransferase by GSNO-triggered S -nitrosylation has been proposed to be an important regulatory mechanism in ethylene synthesis (Lindermayr et al., 2006), while modification of PRX by S -nitrosylation has been implicated in the regulation of ROS signaling (Romero-Puertas et al., 2007)

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