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Chronic exposure to tobacco smoking has a direct effect on the microvascular compartment, which could be the cause of the observed subtle functional systolic impairment

Anderson SJ, McCandless PM, Klausner K, Taketa R, Yerger VB (2011) Tobacco documents research methodology

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For children 12 and older in the United States, difficult, low-paying and dangerous work in tobacco fields for unlimited hours is legal, as long as it's outside school hours

Further, the impact of a tax on e-cigarettes on health and the associated costs over the long term is unknown, because e-cigarettes are relatively new devices and the health impacts of e-cigarettes are still being studied