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Further development of TGR-based therapeutic approaches is impeded by the lack of non-covalent small molecule inhibitors of TGR, a well-known and general problem for all the members of the high molecular weight, Sec-containing TrxR subfamily that are considered attractive and unexploited drug targets for several human diseases 21,22

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Khatun S, Appidi T, Rengan AK

It is rarely used alone

The following protease inhibitors must be removed prior to thrombin or factor Xa cleavage: AEBSF, APMSF, antithrombin III, antipain, 1 -antitrypsin, aprotinin, chymostatin, hirudin, leupeptin, and PMSF