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But the mechanism behind Epithalons sleep effect is indirect and distinct from other peptides that act on sleep directly, a distinction that matters for patient selection

10.1055/a-1792-2678 86 RubioloJ

In two multicenter studies of over 1,500 patients requiring NSAID therapy, HZT-501 demonstrated a ~55% reduction in the risk of ulcer (determined by endoscopy) compared to ibuprofen alone over 24 weeks (Laine 2012)

It should be noted that the human brain with its multimodal structure has undergone dramatic changes in brain regions such as the frontal and temporal lobes during evolution