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GPX4 is the only cellular enzyme that specifically reduces phospholipid hydroperoxides to lipid alcohols using GSH as a co-factor 4 , and inhibiting the cyst(e)ine/GSH/GPX4 axis induces the strongest cell death in most cellular contexts

2023) also reported changes in cellular levels of glutathione content

54 NietzelT.MostertzJ.RubertiC.NeG.FuchsP.WagnerS.et al (2020)

However, mutation of the active cysteine residue induces a significant loss of catalytic efficiency as well as GSH binding affinity at the G-site 19,20,21

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