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She was a 31-year-old Harvard Law School graduate when, in 1972, she beat a five-decade incumbent, Emanuel Celler, to win a Brooklyn, New York, seat in the House of Representatives

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If p53 is mutated, unable to function as a transcriptional regulator, and unable to mediate apoptosis, cells can continue to divide without DNA repair, chromosomal damage may occur and magnify with each cell division, and neoplasia can ensue (see Figure 2)

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