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Use of an endotoxin-free peptide is critical in laboratory environments, as endotoxin interference can significantly alter signaling data and immune-related assay outcomes

Acknowledgments We express our gratitude to BioRender (www.BioRender.com) for their graphical assistance during the preparation of this manuscript

Abstract Background lipedema is a chronic, progressive adipose disorder predominantly affecting women, characterized by painful, symmetrical subcutaneous fat accumulation, and typically resistant to lifestyle interventions