These benefits were linked to the activation of Nrf2, as evidenced by elevated expression of Nrf2-regulated genes such as GST, HO-1, and GSx in the cortex and cerebral microvessels [245]
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Severe kidney problems (label caution in some countries)
493 Firstly, NMNAT acts as a stress-response protein that aids the clearance or refolding of misfolded proteins like a chaperone