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Activation of liver AMPK with PF-06409577 corrects NAFLD and lowers cholesterol in rodent and primate preclinical models

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Although several studies have demonstrated the efficacy of RSL3 in various animal models (31, 32), non-specific effects of RSL3 cannot be excluded given its poor bioavailability in vivo ( To date, the majority of studies regarding drug-tolerant persister cells have focused on persister cells from immortalized cell lines, demonstrating that they occur as a small subset of the total tumor population (33)

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