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The foundational mechanism papers from the Washington State University lab were retracted in April 2025 after a misconduct finding of image manipulation

[DOI] [PMC free article] [PubMed] [Google Scholar] 382.Den Hartogh D., MacPherson R., Tsiani E

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Early medication use in new-onset rheumatoid arthritis may delay joint replacement: results of a large population-based study

First, in the process of disrupting the IGF-1/IGFBP complex by acid/ethanol precipitation, there is the potential IGF-1 loss, which would directly affect the measurements accuracy