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[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment

A., Posey, D

(2020, February 17)

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"Twice daily N-acetylcysteine 600 mg for exacerbations of COPD (PANTHEON)." Lancet Respir Med