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Theoretical Risks with Chronic Use Some concerns raised by clinicians and researchers include: Unregulated angiogenesis: Overstimulation of blood vessel growth could hypothetically support tumor progression in cancer-prone individuals Unknown hormonal crosstalk: While BPC-157 is non-hormonal, it interacts with systems (e.g., nitric oxide, dopamine) that may influence downstream signaling Immune tolerance or desensitization: Chronic exposure to any peptide could alter immune recognition or receptor sensitivity over time These concerns are theoretical , but they highlight why BPC-157 should not be used indefinitely or in uncontrolled cycles

doi: 10.3389/fimmu.2024.1478374 144 HuangWYinHYangYJinLLuGDangZ

Natural compounds such as resveratrol and berberine have demonstrated the ability to modulate GSK-3 activity, thereby reducing tau pathology (Wang M

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Peer review Peer review information Nature Communications thanks Matteo Villa, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work