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Canadian athletes training outdoors during winter months already receive significant cold exposure

Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist

Foods high in B12 include fish, meat, poultry, eggs, dairy produce, and foods that are fortified with B12 (like some breakfast cereals.) If you follow a restrictive diet or have a condition that impacts absorption, you could be at risk for a B12 deficiency