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Mice with hepatocellular carcinoma and treated with XL413 (100 mg/kg) in combination with AZD8055 (20 mg/kg) exhibited significantly greater tumor mass reduction and increased lifespan compared to mice treated with monotherapy using either of these drugs [136]

In addition, we did not find a significant non-linear relationship between dose (g/day) (coefficients = 8.54, p = 0.054) and changes in HOMA-IR, although there was a significant non-linear relationship between duration of the intervention (coefficients = 0.22, p = 0.015) and changes in HOMA-IR

Holmes AH, Moore LSP, Sundsfjord A, Steinbakk M, Regmi S, Karkey A, et al

Disorders related to the cardiovascular system (exercise intolerance, chest pain, palpitations, thrombotic manifestations) are also frequent and potentially pathogenetically related to the dysfunction of the cardiovascular autonomic system

Antioxidants (2021) 10(6):837