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In rare cases, folate deficiency is associated with megaloblastic anemia and birth defects, especially neural tube defects, in children born to mothers with folate deficiency

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Compounding pharmacies recognized these patterns and began including B12 as a preventive measure

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Researchers also investigate its function in maintaining protein thiol homeostasis, regulating enzyme activity through protein glutathionylation, and serving as a cofactor for glutathione peroxidase enzymes that neutralize lipid peroxides and hydrogen peroxide