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For example, lactate can activate the HIF-1 pathway in microglia to enhance pro-inflammatory cytokine release, while IL-1 can inhibit neuronal PGC-1 expression to impair mitochondrial biogenesis, forming a potential link between peripheral immune metabolic reprogramming and central neuroinflammation and energy deficiency

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PMID: 291503

The results suggested that 30 min pre- or post-irradiation treatment of mitoperoxidase 2 significantly protected the mouse embryonic cells from radiation (10 Gy)-induced apoptosis by reducing the extent of mitochondrial ROS generation and lipid peroxidation

Osteogenesis enhancement of silk fibroin/-TCP cement by N-acetyl cysteine through Wnt/-catenin signaling pathway in vivo and vitro