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For many researchers, the slightly lower efficacy is offset by fewer side effects and better day-to-day quality of life

The majority of these events were mild to moderate in severity and transient, occurring during dose escalation and resolving over days to weeks as participants adapted

These advancements have significantly improved the quality of life for millions of people with diabetes worldwide

Trial in progress: Phase 1 study of BI 1823911, an irreversible KRASG12C inhibitor targeting KRAS in its GDP-loaded state, as monotherapy and in combination with the pan-KRAS SOS1 inhibitor BI 1701963 in solid tumors expressing KRASG12C mutation

The difference in cagrilintide doses used between the two studies was based on the available evidence at the time the studies were planned