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To understand the underlying mechanisms, inhibitors targeting the Notch pathway (DAPT) and NF-B pathway (BMS) were also applied to HUVEC and murine CLI models

Peptide stability and delivery studies : The physicochemical properties of Dihexa, including its resistance to enzymatic degradation and favorable membrane permeability, are of particular interest in formulation science and peptide delivery research

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Functional validation using receptor-deficient models confirms that 3-adrenergic signaling is required for these effects, as disruption of this pathway attenuates peptide-induced lipolysis