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Additionally, the truncation appears to enhance IGF-1 receptor (IGF-1R) binding affinity, possibly through conformational changes that optimize receptor interaction

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Lifestyle interventions remain foundational, but maintaining weight loss is challenging, with most patients regaining 80% of lost weight within five years

For researchers, these findings highlight Epithalon as an intriguing tool for exploring pineal-pineal axis regulation, chronobiology, and age-associated endocrine decline