Przedkliniczne dane toksykologiczne: Badania toksycznoci ostrej i podostrej u szczurw nie ujawniy adnej miertelnoci ani istotnej toksycznoci narzdowej, nawet przy dawkach znacznie przekraczajcych dawki terapeutyczne (do 100-krotnoci dawki skutecznej)
TCN2-Cbl is internalized by cells through receptor-mediated endocytosis, which is facilitated by transmembrane CD320 protein
MP0250, a VEGF and HGF neutralizing DARPin molecule shows high anti-tumor efficacy in mouse xenograft and patient-derived tumor models
Inflammatory M1 macrophages also exhibit distinct iron-handling features, including increased expression of ferritin (FtH, FtL) and hepcidin, coupled with reduced FPN1, promoting intracellular iron retention (95, 107, 108)
China Patent CN101921712 (B) Perricone C, Carolis C de, Perricone R (2009) Glutathione: a key player in autoimmunity