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Other proteins that bind KEAP1 and interfere with KEAP1-NRF2 interaction, promoting NRF2 accumulation and function in the nucleus, include: phosphoglycerate mutase 5 (PGAM5, a serine/threonine phosphatase related to the phosphoglycerate mutase family), which has been reported to be associated with mitochondria, so its interaction with KEAP1 may be regulated by mitochondrial signalling processes [187, 188]

Incidence of esophageal adenocarcinoma in patients with Barretts esophagus and high-grade dysplasia: a meta-analysis

It even fine-tunes proteins through a process called S-glutathionylation , which can protect enzymes, adjust their function, or prevent further damage

38(4):329-35 (2015) Li F, Cao J, Liu Q, Hu X, Liao X, Zhang Y